The eukaryotic nucleus contains all the information required to build an organism. This is achieved through a multitude of interactions between the DNA and the proteins that package and regulate the DNA in the nucleus, i.e. chromatin. While the DNA has been fully sequenced, many unknowns remain regarding the nature and dynamics of the interactions between the protein and nucleic acid components of chromatin, both in terms of structural organization and of the regulation of gene activity and other DNA-templated processes. In recent years insights from quantitative single-cell and single-molecule approaches have led to the realization that cell-to-cell variability and the stochastic nature of molecular events, as well as physical phenomena such as phase separation, are central to chromatin biology. As the complexity of nuclear processes is becoming ever more apparent, there is a growing need for the integration of data from the different techniques to study them. Therefore, the scope of the IUBMB Focused Meeting on Integrative Omics of Nuclear Function is to provide a wider perspective of how advanced genomic, proteomic, and imaging approaches can be combined to investigate nuclear structure and function. An important goal of the meeting is to foster exchange between scientists employing diverse experimental and computational approaches to investigate different aspects of chromatin biology to integrate and visualize protein and DNA networks to better understand the dynamics of nuclear processes.
The scientific program of the meeting includes lectures by leaders in the field and up-and-coming talents, organized in 10 scientific sessions and 3 Keynote Lectures with a total of 32 invited speakers. Junior scientists will have the opportunity to present their work in selected short oral presentations and in two poster sessions. Each poster session will also be accompanied by “poster flash talks”. The program includes a “problem solving” session for the participants to personally interact with expert speakers to discuss specific aspects of their research project. Lastly, the program includes Women in Science and Science in Society Lectures and a Round Table discussion of current and future challenges in nuclear biology to conclude the meeting.